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Year: 2019

His race against ALS: Justin Ichida

  • Author By lytal
  • Publication date December 6, 2019
  • Categories: News

Justin Ichida regularly gets emails from strangers asking the same urgent question: “Will your research on ALS be done in time to save my life?” The emails are a constant reminder that he’s in a race against time. “I don’t really know them, but they tell me their whole story,” says Ichida, Richard N. Merkin…Continue Reading His race against ALS: Justin Ichida

Meet six USC Stem Cell postdocs-turned-professors

  • Author By lytal
  • Publication date November 13, 2019
  • Categories: News

Only 23 percent of biomedical PhD holders eventually land tenure-track faculty positions, according to a report by the National Institutes of Health Biomedical Research Workforce Working Group. Beating these odds, six postdoctoral trainees from USC’s Department of Stem Cell Biology and Regenerative Medicine recently landed coveted jobs as tenure-track assistant professors: Lori O’Brien at the…Continue Reading Meet six USC Stem Cell postdocs-turned-professors

Ichida Lab publishes new paper in Cell Stem Cell

  • Author By sbianco
  • Publication date September 15, 2019
  • Categories: News
Cell Stem Cell Cover Ichida

Kim Babos and colleagues fro the Ichida Lab developed a method to reprogram cells to switch their identity much more reliably than present capabilities allow. The technique uses enzymes to untangle reprogramming DNA, somewhat similar to conditioning tangled hair. The technique works with near-perfect efficiency — in mice and humans — for all types of…Continue Reading Ichida Lab publishes new paper in Cell Stem Cell

Ichida Lab publishes new paper in Cell Stem Cell

Kim Babos and colleagues in the Ichida Lab developed a method to reprogram cells to switch their identity much more reliably than present capabilities. The technique uses enzymes to untangle reprogramming DNA somewhat similar to how a coiffeur conditions tangled hair. The technique works with near-perfect efficiency – in animals and humans – for all…Continue Reading Ichida Lab publishes new paper in Cell Stem Cell

USC scientists surmount big obstacle to reprogram cells

  • Author By sbianco
  • Publication date September 12, 2019
  • Categories: News
Cell Stem Cell Cover Ichida

USC scientists have surmounted a big roadblock in regenerative medicine that has so far constrained the ability to use repurposed cells to treat diseases. The researchers figured out how to reprogram cells to switch their identity much more reliably than present capabilities. The technique uses enzymes to untangle reprogramming DNA somewhat similar to how a…Continue Reading USC scientists surmount big obstacle to reprogram cells

Lab publishes new paper in JCI Insight

  • Author By lytal
  • Publication date July 17, 2019
  • Categories: News

Yingxiao (TK) Shi and colleagues in the Ichida Lab developed induced motor neuron (iMN) models from C9ORF72 and sporadic ALS (sALS) patients, which together comprise ~90% of patients. iMNs from C9ORF72 and several sporadic ALS patients share two common defects involving autophagosomes and glutamate receptors. An anticoagulation-deficient form of activated protein C, 3K3A-APC, rescues these…Continue Reading Lab publishes new paper in JCI Insight

Yichen Li and Justin Ichida publish preview in Cell Stem Cell

  • Author By lytal
  • Publication date July 10, 2019
  • Categories: News

Direct lineage conversion offers a fast and simple method to study mature neurons in vitro, but its utility for investigating neurodevelopment has remained unclear. Yichen Li and Justin Ichida preview research by Chanda et al. (2019), using Ngn2-induced neurons to elucidate the pathogenic mechanisms of the teratogenic compound valproic acid. To read the preview, visit…Continue Reading Yichen Li and Justin Ichida publish preview in Cell Stem Cell