Lab publishes new paper in JCI Insight

Yingxiao (TK) Shi and colleagues in the Ichida Lab developed induced motor neuron (iMN) models from C9ORF72 and sporadic ALS (sALS) patients, which together comprise ~90% of patients. iMNs from C9ORF72 and several sporadic ALS patients share two common defects involving autophagosomes and glutamate receptors. An anticoagulation-deficient form of activated protein C, 3K3A-APC, rescues these defects in both C9ORF72 and sporadic ALS iMNs. To read the paper, visit