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Recent Publications

  1. Yu, SF, Michon, M, Lingappa, AF, Paulvannan, K, Solas, D, Staats, K et al.. An ALS assembly modulator signature in peripheral blood mononuclear cells: implications for ALS pathophysiology, therapeutics, and diagnostics. Clin Proteomics. 2025;22 (1):16. doi: 10.1186/s12014-025-09538-4. PubMed PMID:40295933 PubMed Central PMC12036218.
  2. Salomon-Zimri, S, Kerem, N, Linares, GR, Russek-Blum, N, Ichida, JK, Tracik, F et al.. Elucidating the Synergistic Effect of the PrimeC Combination for Amyotrophic Lateral Sclerosis in Human Induced Pluripotent Stem Cell-Derived Motor Neurons and Mouse Models. Pharmaceuticals (Basel). 2025;18 (4):. doi: 10.3390/ph18040524. PubMed PMID:40283960 PubMed Central PMC12030000.
  3. Berlind, JE, Lai, JD, Lie, C, Vicente, J, Lam, K, Guo, S et al.. KCTD20 suppression mitigates excitotoxicity in tauopathy patient organoids. Neuron. 2025;113 (8):1169-1189.e7. doi: 10.1016/j.neuron.2025.02.001. PubMed PMID:40049159 PubMed Central PMC12005969.
  4. Santoso, JW, Do, SK, Verma, R, Do, AV, Hendricks, E, Ichida, JK et al.. Human iPSC-Derived Motor Neuron Innervation Enhances the Differentiation of Muscle Bundles Engineered with Benchtop Fabrication Techniques. ACS Biomater Sci Eng. 2025;11 (3):1731-1740. doi: 10.1021/acsbiomaterials.4c02225. PubMed PMID:39973396 PubMed Central PMC11897949.
  5. Santoso, JW, Do, SK, Verma, R, Do, AV, Hendricks, E, Ichida, JK et al.. Human iPSC-derived motor neuron innervation enhances the differentiation of muscle bundles engineered with benchtop fabrication techniques. bioRxiv. 2024; :. doi: 10.1101/2024.12.02.626391. PubMed PMID:39677637 PubMed Central PMC11642770.
  6. Zhang, S, Shu, H, Zhou, J, Rubin-Sigler, J, Yang, X, Liu, Y et al.. Deconvolution of polygenic risk score in single cells unravels cellular and molecular heterogeneity of complex human diseases. bioRxiv. 2024; :. doi: 10.1101/2024.05.14.594252. PubMed PMID:38798507 PubMed Central PMC11118500.
  7. Zhang, S, Moll, T, Rubin-Sigler, J, Tu, S, Li, S, Yuan, E et al.. Deep learning modeling of rare noncoding genetic variants in human motor neurons defines CCDC146 as a therapeutic target for ALS. medRxiv. 2024; :. doi: 10.1101/2024.03.30.24305115. PubMed PMID:38633814 PubMed Central PMC11023684.
  8. Lai, JD, Berlind, JE, Fricklas, G, Lie, C, Urenda, JP, Lam, K et al.. KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury. Cell Stem Cell. 2024;31 (4):519-536.e8. doi: 10.1016/j.stem.2024.03.004. PubMed PMID:38579683 .
  9. Zhao, Z, Sagare, AP, Ma, Q, Halliday, MR, Kong, P, Kisler, K et al.. Author Correction: Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance. Nat Neurosci. 2024;27 (1):208. doi: 10.1038/s41593-023-01509-y. PubMed PMID:37985802 .
  10. Ortega, JA, Sasselli, IR, Boccitto, M, Fleming, AC, Fortuna, TR, Li, Y et al.. CLIP-Seq analysis enables the design of protective ribosomal RNA bait oligonucleotides against C9ORF72 ALS/FTD poly-GR pathophysiology. Sci Adv. 2023;9 (45):eadf7997. doi: 10.1126/sciadv.adf7997. PubMed PMID:37948524 PubMed Central PMC10637751.