Our lab creates in vitro models of human neurodegenerative diseases by converting patients’ skin fibroblasts into disease-affected neural cells. This enables us to screen thousands of drug-like compounds in search of potential therapeutics that slow or stop the degeneration of these cells in petri dishes — and eventually in patients.
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Human motor neuron grown from an embryonic stem cell (ESC-MN) in the neuromuscular junction with a chick muscle (Image courtesy of the Ichida Lab) -
Human chemical induced pluripotent stem cell (iPSC) colony with NANOG-TRA-1-81 staining (Image courtesy of the Ichida Lab) -
Human chemical iPSC colony with NANOG-TRA-1-81-DAPI staining (Image courtesy of the Ichida Lab) -
Human iPSC-derived neurons with TUJ1 staining (Image courtesy of the Ichida Lab) -
Human induced motor neurons (iMNs) (Image courtesy of the Ichida Lab) -
Mouse chemical iPSC colony with Oct4 marked with green fluorescent protein (GFP) (Image courtesy of the Ichida Lab) -
Cerebral organoid derived from ALS patient stem cells (Image by Lisa Nguyen, Yaoming Wang and Angeliki Nikolakopoulou)
