University of Southern California

Ichida Lab

USC Stem Cell

Lab Overview

Our lab creates in vitro models of human neurodegenerative diseases by converting patients’ skin fibroblasts into disease-affected neural cells. This enables us to screen thousands of drug-like compounds in search of potential therapeutics that slow or stop the degeneration of these cells in petri dishes — and eventually in patients.

How to Reprogram Cells … and Why that Matters to Patients
Cerebral organoid derived from ALS patient stem cells (Image by Lisa Nguyen, Yaoming Wang and Angeliki Nikolakopoulou)
Human motor neuron grown from an embryonic stem cell (ESC-MN) in the neuromuscular juntion with a chick muscle (Image courtesy of the Ichida Lab)
Human chemical induced pluripotent stem cell (iPSC) colony with NANOG-TRA-1-81 staining (Image courtesy of the Ichida Lab)
Human chemical iPSC colony with NANOG-TRA-1-81-DAPI staining (Image courtesy of the Ichida Lab)
Human iPSC-derived neurons with TUJ1 staining (Image courtesy of the Ichida Lab)
Human induced motor neurons (iMNs) (Image courtesy of the Ichida Lab)
Mouse chemical iPSC colony with Oct4 marked with green fluorescent protein (GFP) (Image courtesy of the Ichida Lab)